Successful trovafloxacin prophylaxis against experimental streptococcal aortic valve endocarditis.
نویسندگان
چکیده
Single-dose trovafloxacin (15 mg/kg given intravenously [i.v.]) and ampicillin (40 mg/kg given i.v.) protected 38 and 33% of animals challenged with an ampicillin-tolerant strain of Streptococcus oralis, respectively. As a double-dose regimen, trovafloxacin afforded total protection (100%; P < 0.001 versus controls). Trovafloxacin is the first fluoroquinolone effective in preventing experimental streptococcal endocarditis.
منابع مشابه
Successful moxifloxacin prophylaxis against experimental streptococcal aortic valve endocarditis.
OBJECTIVES Studies related to the prophylactic efficacy of fluoroquinolones against infective endocarditis are scarce. The aim of this study was to evaluate the efficacy of moxifloxacin, a quinolone active in vitro against Gram-positive cocci, in preventing streptococcal aortic valve endocarditis. METHODS Non-bacterial thrombotic endocarditis of the aortic valve was induced by the insertion o...
متن کاملSingle-oral-dose azithromycin prophylaxis against experimental streptococcal or staphylococcal aortic valve endocarditis.
Azithromycin and ampicillin protected 94 and 72% of animals challenged with Streptococcus oralis, respectively (P = 0.177), while azithromycin and vancomycin protected 59 and 94% of the methicillin-resistant Staphylococcus aureus (MRSA)-challenged animals, respectively (P = 0.018). Azithromycin is effective in preventing experimental streptococcal endocarditis, but against MRSA it is less effec...
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The activity of trovafloxacin was compared with those of vancomycin and penicillin in a model of Streptococcus sanguis species group (trovafloxacin MIC, 0.125 microg/ml) and Streptococcus mitis species group (trovafloxacin MIC, 0.125 microg/ml) experimental endocarditis. Rabbits with catheter-induced aortic valve vegetations were given no treatment, trovafloxacin at 15 mg/kg of body weight thre...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 44 9 شماره
صفحات -
تاریخ انتشار 2000